Senior Lecturer - Department of Pharmacy, University of Peradeniya – February 2015,Present.

Research Specialist in Pharmacology and Toxicology (Gratis), School of Pharmacy, University of Connecticut - Nov 2015, Present.

Senior Technical Lead - WSO2 Inc, 20, Palm Grove, Colombo – August 2014, January 2015.

Postdoctoral Research Fellow - School of Pharmacy, University of Connecticut, USA - September 2011, July 2014.

Graduate Assistant - Department of Chemistry, University of Connecticut, USA - September 2006, August 2011.

Temporary Assistant Lecturer - University of Peradeniya - May 2005, May 2006.

B.F. Khan Gold Medal for Best Overall Performance in Chemistry at the Undergraduate Level (2001-2005)-University of Peradeniya, Sri lanka.

Hayleys Award for Best Performance in Chemistry (2002, 2003).

University Award for Academic Excellence (2004, 2005) - University of Peradeniya, Sri lanka.

Silver Medal – Inter University Chemistry Competition (Royal Society of Chemistry, 2006).

NIH-NCRR Travel Grant to attend a workshop titled Methods and Applications of Hybrid QM/MM Simulations to Biomolecular Systems, National Resource for Biomedical Supercomputing(NRBSC)-Pittsburgh Supercomputing Center(PSC), Sep 2007.

Partnership for Excellence in Structural Biology Fellowship - University of Connecticut, USA 2007.

R.T. Major Poster Award University of Connecticut 2008.

Menikarachchi, L. C.; Gascón, J. A. Optimization of Cutting Schemes for the Evaluation of Molecular Electrostatic Potentials in Proteins via Moving-Domain QM/MM. J. Mol. Model. 2008, 14, 479–487

Menikarachchi, L. C. Gascón, J. A. QM/MM Approaches in Medicinal Chemistry Research. Curr. Top. Med. Chem. 2010, 10, 46–54

Menikarachchi, L. C.; Gascón, J. a. An Extrapolation Method for Computing Protein Solvation Energies Based on Density Fragmentation of a Graphical Surface Tessellation. J. Mol. Graph. Model. 2011, 30, 38–45,

Beshir, A. B.; Argueta, C. E.; Menikarachchi, L. C.; Gascón, J. A.; & Gabriel Fenteany. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For. Immunopathol. Dis. Therap. 2011, 2, 47–58

Menikarachchi, L. C.; Cawley, S.; Hill, D. W.; Hall, L. M.; Hall, L.; Lai, S.; Wilder, J.; Grant, D. F. MolFind: A Software Package Enabling HPLC/MS-Based Identification of Unknown Chemical Structures. Anal. Chem. 2012, 84, 9388–93394

Menikarachchi, L. C.; Hill, D. W.; Hamdalla, M. a; Mandoiu, I. I.; Grant, D. F. In Silico Enzymatic Synthesis of a 400 000 Compound Biochemical Database for Nontargeted Metabolomics. J. Chem. Inf. Model. 2013, 53, 2483–2492,

Menikarachchi, L. C.; Hamdalla, M. A.; Hill, D. W.; Grant, D. F. Chemical Structure Identification in Metabolomics: Computational Modeling of Experimental Features. Comput. Struct. Biotechnol. J. 2013, 5

Giuseppe Paglia, Jonathan P. Williams, Lochana Menikarachchi, J. Will Thompson, Richard Tyldesley-Worster, Skarphédinn Halldórsson, Ottar Rolfsson, Arthur Moseley, David Grant, James Langridge, Bernhard O. Palsson, and Giuseppe Astarita, Ion Mobility Derived Collision Cross Sections to Support Metabolomics Applications, Anal. Chem. 2014 86 (8), 3985-3993

Giuseppe Paglia, Peggi Angel, Jonathan P. Williams, Keith Richardson, Hernando J. Olivos, J. Will Thompson, Lochana Menikarachchi, Steven Lai, Callee Walsh, Arthur Moseley, Robert S. Plumb, David F. Grant, Bernhard O. Palsson, James Langridge, Scott Geromanos, and Giuseppe Astarita, Ion Mobility-Derived Collision Cross Section As an Additional Measure for Lipid Fingerprinting and Identification, Anal. Chem. 2015 87 (2), 1137-1144

Paglia G, Menikarachchi LC, Langridge J, Astarita G. Travelling-wave ion mobility-mass spectrometry in metabolomics: workflows and bioinformatic tools. In: Identification and Data Processing Methods in Metabolomics. Rudaz S (Ed). Future Medicine, London, UK. DOI 10.4155/FSEB2013.14.224.

M. L. Hall, Menikarachchi, L. C., Chen, M. - H., and Grant, D. F., Optimizing Artificial Neural Network models for metabolomics and systems biology: an example using HPLC retention index data, Bioanalysis

L.C. Menikarachchi, R. Dubey, D.W. Hill, D.N. Brush, D.F. Grant, Development of Database Assisted Structure Identification (DASI) Methods for Nontargeted Metabolomics, Metabolites 6 (2), 17, doi:10.3390/metabo6020017